EUGENOL AMELIORATES PATHOGENIC FEATURES IN EXPERIMENTAL MODEL OF NAFLD IN RATS

Document Type : Original Article

Author

Demonstrator, Department of Drugs and Toxicology, Faculty of Pharmacy, Egyptian-Russian University

Abstract

Background: Nonalcoholic fatty liver disease (NAFLD) is emerging one of the major causes of chronic liver damage that includes a wide spectrum of liver injury ranging from steatosis to steatohepatitis evolving to fibrosis.
Aim: This study was designed to evaluate the possible effect of EUG on NAFLD induced by high fat cholesterol diet.
Methods:Rats were fed either normal rat chow diet (control) or high fat cholesterol diet and both received olive oil (10 mg/kg) for eight weeks to induce NAFLD model. Eugenol (10 mg/kg) was administrated to rats by oral intubation 3 times weekly for 8 weeks.
Results:Our results showed that EUG significantly ameliorated the histopathological lesions induced by HFCD. Furthermore, HFCD induced a significant elevation in liver enzymes (alanine aminotransferase (ALT) and aspartate aminotransferase (AST)). This was significantly attenuated by EUG co-treatment.
Conclusion:These findings indicate that EUG possess es  a marked role in modulation of NAFLD.

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Al-Azhar Journal of Pharmaceutical Sciences
Volume 56, Issue 2 - Serial Number 2
September and October 2017
Pages 115-122

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