MICROBIAL TRANSFORMATION OF 2,5 DIHYDROXYCINNAMIC ACID BY ASPERGILLUS NIGER AND RHIZOPUS ORYZAE

Document Type : Original Article

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Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt

Abstract

2,5-dihydroxy cinnamic acid (1), when fermented with fungal culture, Rhizopus oryzae RCMB 014002 gave mainly two metabolites; 2,5-dihydroxy cinnamoyl alcohol (Cin-RM-1) and 2-Hydroxy-4,5-dimethoxy cinnamoyl alcohol (Cin-RM-2). Aspergillus niger RCMB002007, however, transformed 2,5-dihydroxy cinnamic acid (1), into a major metabolite;2-hydroxy-5-methoxy cinnamic acid (Cin-AM-3). The structures of the metabolic products were elucidated by means of spectroscopic data. The significance of the metabolites as antioxidants using DPPH radical scavenging assay and lipid peroxidation assay by thiobarbituric acid-reactive substances (TBARS) method using rat tissue homogenates in relation to their structure was discussed.

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