Al-Azhar University, Faculty of Pharmacy
Al-Azhar Journal of Pharmaceutical Sciences
1110-1644
2535-1958
47
1
2013
03
01
EFFECT OF MORINGAOLEIFERA LEAVES EXTRACT AGAINST ACETAMINOPHEN INDUCED HEPATOTOXICITY IN ALBINO RATS.
1
11
EN
Shahenda
Elaby
Regional Center for Food and Feed, Agriculture Research Center, Giza, Egypt
10.21608/ajps.2013.7104
<strong>Abstract</strong>
This study was carried out to evaluate the the effect of <em>moringaoleifera</em>leavesExtract against liver injury induced by APAP in rats.The experimental animals were divided into six groups of male albino rats. Aqueous extract of <em>Moringaoleifera</em> (AMO) and hydroalcoholic extract of <em>Moringaoleifera</em> (HAMO) were prepared and pre-administered orally to rats at dose 500 mg/kg body weight; p.ofor a period of 28 days prior to a singleoraldose of APAP 3 g/kg body weight; p.o.The results showed that APAP induced a significant rise in the activities of aspartate amino transferase(AST), alanine amino transferase (ALT), alkaline phosphatase (ALP)and the level of malondialdehyde (MDA)besides reduction in the activities of glutathione reductase (GR), superoxide dismutase (SOD) and catalase (CAT).The activities of AST, ALT, ALP and the level of MDAwere significantly decreasedwhilethe activities of GR, SOD and CATwere significantlyincreased in rats pre-administered with HAMO and AMO priorto APAP treatmentcompared to the group treated with APAP alone. Rats pre-administered with HAMO priorto APAP treatmenthave provided more significant protectioninthe activities of liver enzymes and antioxidants enzymes than rats pre-administered with AMO priorto APAP treatment.Pre-administered of HAMO and AMO significantly prevented the hepatocellularchanges associated with APAPtreatment.The results from the present study suggestedthat the two extracts of <em>moringaoleifera</em>leaves (HAMO and AMO) possess a remarkablehepatoprotective and antioxidantactivity against APAP induced hepatotoxicity.
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https://ajps.journals.ekb.eg/article_7104.html
https://ajps.journals.ekb.eg/article_7104_2e9e7990de90981e192496c6f21b6f0a.pdf
Al-Azhar University, Faculty of Pharmacy
Al-Azhar Journal of Pharmaceutical Sciences
1110-1644
2535-1958
47
1
2013
03
01
EFFECT OF ASCORBIC ACID, BENZYL ADENINE AND PACLOBUTRAZOL ON GROWTH, YIELD AND SOME METABOLIC CONSTITUENTS OF SUNFLOWER PLANTS
12
21
EN
Emad EL- Dein
Ewais
Botany and Microbiology Department, Faculty of Science, Al-Azhar University, Cairo, Egypt.
10.21608/ajps.2013.7105
A field experiment was conducted to study the effect of foliar spray of ascorbic acid (50 and 100 ppm), benzyl adenine (50 and 100 ppm) and paclobutrazol (25 and 50 ppm) on growth, yield and some physiological parameters of (<em>Helianthus annuus </em>var. Sakha 53). Ascorbic acid was more effective than other treatments in enhancing growth parameters during stage I, while benzyl adenine was most effective during stage II. Paclobutrazol seemed to be less effective regarding growth characteristics. All doses applied tended to increase photosynthetic pigments, total soluble carbohydrates and soluble proteins of sunflower plants. The changes in proteolytic, amylolytic and lipolytic activities were also recorded. This was associated by improving yield quality and the nutritional value of the seeds. The effect of paclobutrazol was superior to that of ascorbic acid, benzyl adenine on increasing yield components. The highest lipid % was recorded by 50 ppm of ascorbic acid, whereas the highest carbohydrates and proteins of the yielded seeds were observed with plants treated with 100 ppm benzyl adenine.
https://ajps.journals.ekb.eg/article_7105.html
https://ajps.journals.ekb.eg/article_7105_2883527311721153941d585f3131c1c7.pdf
Al-Azhar University, Faculty of Pharmacy
Al-Azhar Journal of Pharmaceutical Sciences
1110-1644
2535-1958
47
1
2013
03
01
FORMULATION AND EVALUATION OF CONTROLLED DELIVERY FLOATING MICROSPHERES OF RANITIDINE HYDROCHLORIDE
22
35
EN
Ahmed
Samy
Department of pharmaceutics, Faculty of Pharmacy, Al Azhar University, Egypt.
10.21608/ajps.2013.7106
<strong>Aim: </strong>the objective of the present paper was to design and formulate Ranitidine hydrochloride (RH) floating microspheres by the emulsion solvent evaporation technique using different polymers: [Ethyl cellulose (EC) and Eudragit E100 (E E100)] with different drug: polymer ratio and at different speeds of rotation.
<strong>Methodology</strong>: the emulsion solvent- evaporation technique was used for the preparation of Ranitidine floating microspheres. The prepared microspheres were examined for their production yield, entrapment efficiency, micromeritic properties, in- vitro buoyancy and in-vitro drug release.
<strong>Results and discussion:</strong> Evaluation of micromeretics properties of the prepared microspheres showed that all formulae have good flow properties. The production yield of the microspheres ranging from 60.7% to 98.7% [the best one was (RH-EC/E E100 (1:2.5)400 rpm)] and encapsulation efficiencies ranging from 47.5% to 79.7% [the best one was (RH-EC (1:4)400 rpm)].Microspheres showed excellent buoyancy ranging from72% to 92% over 12hr [the best one was (RH-E E100 (1:1)400 rpm)] as RH microspheres with low density showed excellent floatation behavior than others with high density. In vitro release of the drug showing a biphasic pattern with controlled release during 12 hours. The release of RH increased as the concentration of polymer decreased. By combining the production yield, micromeretics parameters, entrapment efficiency and the in vitro release of RH from capsules, it was found that RH-EC/E E100 (1:2.5) 400 rpm was superior to all of the prepared formulae.
RH (Ranitidine hydrochloride),EC (Ethyl cellulose) and E E100 (Eudragite E100)
https://ajps.journals.ekb.eg/article_7106.html
https://ajps.journals.ekb.eg/article_7106_6a397e8312d59e779ebc1f40180d6b9c.pdf
Al-Azhar University, Faculty of Pharmacy
Al-Azhar Journal of Pharmaceutical Sciences
1110-1644
2535-1958
47
1
2013
03
01
DESIGN, FORMULATION AND EVALUATION OF CELECOXIB SOLID DISPERSIONS PREPARED BY THE SOLVENT- EVAPORATION TECHNIQUE
36
53
EN
Yasmin
Mortagi
Department of Pharmaceutics, Faculty of Pharmacy and Pharmaceutical Industries, Sinai University, El-Arish, North Sinai, Egypt.
10.21608/ajps.2013.7107
The aim of the present study was to improve dissolution of poorly water-soluble Celecoxib by solid dispersion technique using water soluble carriers. Solid dispersions of Celecoxib were prepared with different polymers or carriers such as Hydroxy Propyl Beta Cyclodextrin, polyvinylpyrrolidone (PVP K30) and Urea. Solid dispersions were formulated in drug polymer ratio 1:2.5, 1:5, 1:7.5 and 1:10 using solvent evaporation method. The prepared formulae were assayed for drug content, production yield and micromeritics properties. Dissolution profiles were done in water containing 1% sodium lauryl sulphate and the in-vitro release was ranked according to the % drug released after 60 and 120 minutes. The results indicated that all of the formulated solid dispersions displayed better dissolution profiles as compared to the pure drug. Formula containing drug to HP-β-CD (1:10) was ranked first and gave the best results out of the 12 solid dispersion formulae prepared.
Celecoxib,Solid dispersion,dissolution enhancement,solvent evaporation
https://ajps.journals.ekb.eg/article_7107.html
https://ajps.journals.ekb.eg/article_7107_971d225f5318a3b43f2ebe26059241c2.pdf
Al-Azhar University, Faculty of Pharmacy
Al-Azhar Journal of Pharmaceutical Sciences
1110-1644
2535-1958
47
1
2013
03
01
PRODUCTION OF POLYHYDROXYBUTERATE (PHB) FROM INDUSTERIAL WASTE
54
62
EN
Gmal
Gabr
Department of Pharmacology, Faculty of Pharmacy, Salman Bin Abdul-Aziz University, KSA
10.21608/ajps.2013.7108
Biodegradable polymers are of reasonable medical and agricultural applications nowadays. Samples from various natural environments in South Riyadh area, Saudi Arabia, were screened for microorganisms that are capable of producing poly (3-hydroxybutyrate-co-4- hydroxybutyrate). A total of 50 isolates were collected and two out of those were identified as possible PHA producers based on Nile red staining methods. The isolate NG-2 obtained in this study was cultivated in MSM containing date palm syrup as inexpensive carbon source for economic production. Moreover, PHA was extracted from the NG-2 isolate and analyzed by IR followed by electron microscope to confirm the capability of producing PHB. Efforts have been paid to determine the optimal condition of the culture growth and its biodegradation activity. It was found that despite of the type of the polymer-containing media used, the optimum incubation temperature for the tested microorganism was 37°C, while pH value of 7.2 resulted in the best growth pattern in date palm syrup at concentration of 8 % containing media.
Our major goal is to develop biodegradable drug carriers as effective drug delivery systems that release particular nutrient or drug at a particular site. This biotechnology of biological delivery has a unique physiochemical and mechanical properties help in field of pharmaceutical and nutraceutical targeting. This sort of nanotechnology will appear in subsequent works.
marine bacteria _ Polyhydroxyalkanoate _ Nile red _ PHA producer _
https://ajps.journals.ekb.eg/article_7108.html
https://ajps.journals.ekb.eg/article_7108_489e6bd4f239733e8076b451ea6b719e.pdf
Al-Azhar University, Faculty of Pharmacy
Al-Azhar Journal of Pharmaceutical Sciences
1110-1644
2535-1958
47
1
2013
03
01
SOME HERBAL MEDICINE TRADITIONALLY USED IN SOUTH JORDAN "AL-KARAK REGION" BETWEEN ITS CLAIMED MEDICAL EFFECTS AND ITS DOCUMENTED EXPERIMENTAL FOUNDS.
63
82
EN
Lidia
Al-Halaseh
Pharmaceutical Science, Al-Balqaa Applied University, Jordan"
10.21608/ajps.2013.7109
This study evaluates the traditional use of 16 sixteen wild medicinal plants and spices act as a complementary and alternative medicine used by patients in south Jordan "Al-Karak region"<em>.</em>
These plants, which frequently prescribed by the Herbalist "Attarin" are:
<em>Peganum harmala, Portulaca oleracea portulacaceaee, Ricinus communis, Matricaria aurea compositae, Pimpinella anisum Umbelliferae, Nigella sativa, cinnamomum zeylanicum lauracea, Foeniculum vulgare, Rosmarinus officinalis labiatae, Hibiscus sabdariffa, cuminum cyminum,,Zingiber officinale, Artemisia vulgaris, Thymus vulgaris, Trigonella foenum-graecum, Crocus sativus.</em>
These plants are studied for their claimed properties in healing diseases in Gastrointestinal, immune, Respiratory, cardiovascular, dermal, genitourinary, memory difficulties, nervous systems and others
https://ajps.journals.ekb.eg/article_7109.html
https://ajps.journals.ekb.eg/article_7109_4cd46cec790bd80dab31ba1d31a7faa6.pdf
Al-Azhar University, Faculty of Pharmacy
Al-Azhar Journal of Pharmaceutical Sciences
1110-1644
2535-1958
47
1
2013
03
01
THE EFFECT OF BETACYCLODEXTRIN ON THE SOLUBILITY AND DISSOLUTION OF SPIRONOLACTONE USING PHYSICAL MIXING AND CO-EVAPORATION METHODS
83
94
EN
Khaled
Saleh
Dept. of Pharmaceutics and Industrial Pharamcy, Faculty of Pharmacy,
Al-Azhar University, Assiut Branch.
10.21608/ajps.2013.7110
Spironolactone is a steroidal drug acting as a specific aldosterone antagonist used as potassium sparing diuretic. It shows variable absorption and bioavailability due to its poor solubility. The objective of this study was to investigate the effect of betacyclodextrin (BCD) on the solubility and dissolution of spironolactone using physical mixing and co-evaporation methods. The physical mixtures of different w/w drug/carrier ratios (1:1, 1:2 and 1:3) were prepared by simple mixing. Also co-evaporate systems containing (1:1, 1:2 and 1:3) w/w drug/carrier ratios were prepared. The physicochemical characterization of the systems using differential scanning calorimetry (DSC) and powder X-ray diffraction was carried out to detect the interaction between the drug and the carrier, moreover, quantitative solubility and in-vitro dissolution studies of spironolactone alone and in physical mixtures or co-evaporates were studied in simulated gastric fluid (SGF) of pH 1.2 and in simulated intestinal fluid (SIF) of pH 7.5.
The reduction of drug peaks in X-ray diffraction pattern of the co-evaparate and the absence or reduction of drug peaks in DSC profile of the physical mixture and the co-evaporate suggest the transformation of crystalline spironolactone into an amorphous form due to the inclusion complexation with betacyclodextrin. The study showed an increase in the solubility values and an improvement in the dissolution pattern of the drug in case of the physical mixtures and the co-evaporates.
https://ajps.journals.ekb.eg/article_7110.html
https://ajps.journals.ekb.eg/article_7110_f3fb6c11eac77ec999f4703b888f31ac.pdf
Al-Azhar University, Faculty of Pharmacy
Al-Azhar Journal of Pharmaceutical Sciences
1110-1644
2535-1958
47
1
2013
03
01
QUANTITIVE EVOLUTION OF WITHANOLIDES CONTENT OF EGYPTIAN WITHANIA SOMNIFERA (L.) ROOTS.
95
104
EN
Said
Ismail
Al-Azhar University, Faculty of Pharmacy, Pharmacognosy Department, Cairo, Egypt.
10.21608/ajps.2013.7112
Withanolides are important secondary metabolite in Withania somnifera (L.), which have high medicinal values and possess potent anti-tumor and antioxidant properties. A simple, rapid and specific reversed-phase HPLC method for the simultaneous analysis of nine structurally similar withanolides, namely, Withanolides A, B, IV, V, withanone, 27-hydroxywithanone, withaferin A, withastramonolide and physagulin D of root tissues of Withania somnifera, collected from Egypt, has been developed using a linear binary gradient solvent system comprising of (<strong>A</strong>) 0.14 g of potassium dihydrogen phosphate in 900 mL of water, 0.5 mL of phosphoric acid, dilute with water to 1000 mL, and (<strong>B</strong>) acetonitrile were used to profile the extract compositions and to quantify the withanolides therein. Homogeneity and purity of each peak was ascertained by comparative evaluation of the on-line UV spectra of the eluted compounds with those of the reference compounds. The method described can be easily and reliably applied to the quantitative analyses of withanolides in roots of Withania somnifera L.
https://ajps.journals.ekb.eg/article_7112.html
https://ajps.journals.ekb.eg/article_7112_f3fdb59a66c7545a6809eae60a803833.pdf