The thermal condensation of 2,4-diamino 5-bromo-6-hydroxypyrimidine with 2-amino-3-mercaptopropylaniline derivatives (6) and 2-amino-3-mercaptopropymethyllaniline derivatives (9) resulted in 2,4-diamino-6-substituted anilinomethlyl 6,7-dihydro-8H-pyrimido[4,5-b][1,4] thiazine derivatives (13, R= H) and 2,4-diamino-6-substituted methylanilinomethlyl 6,7-dihydro-8-methyl-pyrimido[4,5-b][1,4] thiazine derivatives (13, R= CH3) respectively. The synthesized compounds were screened for antimicrobial activity and it was found that the screened compounds have antimicrobial and antifungal activity comparable to chloramphenicol and terbinafine.
Sakr, H. (2015). DESIGN, SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME NEW 2,4-DIAMINO PYRIMIDOTHIAZINE DERIVATIVES. Al-Azhar Journal of Pharmaceutical Sciences, 52(2), 82-100. doi: 10.21608/ajps.2015.12534
MLA
Helmy Sakr. "DESIGN, SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME NEW 2,4-DIAMINO PYRIMIDOTHIAZINE DERIVATIVES". Al-Azhar Journal of Pharmaceutical Sciences, 52, 2, 2015, 82-100. doi: 10.21608/ajps.2015.12534
HARVARD
Sakr, H. (2015). 'DESIGN, SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME NEW 2,4-DIAMINO PYRIMIDOTHIAZINE DERIVATIVES', Al-Azhar Journal of Pharmaceutical Sciences, 52(2), pp. 82-100. doi: 10.21608/ajps.2015.12534
VANCOUVER
Sakr, H. DESIGN, SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME NEW 2,4-DIAMINO PYRIMIDOTHIAZINE DERIVATIVES. Al-Azhar Journal of Pharmaceutical Sciences, 2015; 52(2): 82-100. doi: 10.21608/ajps.2015.12534
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