NEPHROPROTECTIVE EFFECT OF METFORMIN AGAINST GLYCEROL-INDUCED ACUTE KIDNEY INJURY IN RATS

Document Type : Original Article

Author

Pharmacology and Toxicology Department, Pharmacy College (girls), Al-Azhar University, Cairo, Egypt

Abstract

Rhabdomyolysis-associated acute kidney injury (AKI) is a serious life-threatening condition. Therefore, more effective strategies are needed for its prevention. The pathophysiological process of rhabdomyolysis-associated AKI involves oxidative stress, inflammation and apoptosis. Metformin (MF) has been known to possess antioxidant, anti-inflammatory and antiapoptotic properties. This study explored the possible effect of pretreatment with metformin on the development of glycerol-induced-AKI in rats.