DESIGN AND SYNTHESIS OF NOVEL TERREMIDE DERIVATIVES FOR PHARMACOLOGICAL EVALUATION

Elsebaei, Mohamed; Mancy, Ahmed; Mayhoub, Abdelrahman; Ayman, Mohamed

doi:10.21608/ajps.2022.268386

DESIGN AND SYNTHESIS OF NOVEL TERREMIDE DERIVATIVES FOR PHARMACOLOGICAL EVALUATION

Document Type : Original Article

Authors

¹ Department of Pharmaceutical Organic Chemistry, College of Pharmacy(boys), Al-Azhar University, Cairo 11884, Egypt.

² Department of Pharmaceutical Organic Chemistry, College of Pharmacy(boys), Al-Azhar University, Cairo 11884, Egypt. Nanoscience Program, University of Science and Technology, Zewail City of Science and Technology, Giza, Egypt

³ Department of Pharmaceutical Medicinal Chemistry & Drug Design Department, College of Pharmacy(boys), Al-Azhar University, Cairo 11884, Egypt.

10.21608/ajps.2022.268386

Abstract

clinicians and chemists are directed in those days toward the biologically active compounds to reduce the mortality and morbidity. Quinazolines were reported previously as a scaffold that possesses antitumor and antimicrobial activities. Close inspection of the structure-activity-relationships (SAR) of quinazolines revealed important structural features necessary for their antimicrobial activity: a nitrogenous ring and a side chain. Using quinazoline heterocyclic compound to try to synthesize compounds similar to terremide to enhance the activity. In the present work, advantageous moieties have been combined together to generate new hybrid scaffolds of quinazoline with the objective of synthesizing new moieties enhancing the antimicrobial biological activityand drug-like properties.

Keywords