AN OVERVIEW OF IMIDES AND THEIR ANALOGUES AS ANTICANCER AGENTS

El-Zahabi, Mohamed; Amin, Yahia; Sakr, Helmy; El-Hady, Omar

doi:10.21608/ajps.2022.268400

AN OVERVIEW OF IMIDES AND THEIR ANALOGUES AS ANTICANCER AGENTS

Document Type : Original Article

Authors

¹ Department of Pharmaceutical Medicinal Chemistry & Drug Design, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo 11884, Egypt.

² Department of Chemistry, Faculty of Science, Sohag University, 82852 Sohag, Egypt.

³ Department of Pharmaceitical Medicinal Chemistry & Drug Design, Faculty of Pharmcy (Boys), Al-Azhar University,Cairo 11884, Egypt.

10.21608/ajps.2022.268400

Abstract

In this review article, we highlight the history of cancer immunotherapy; different types of cancer diseases, different stage of cancers, gene mutations are involved in cancer pathogenesis as well as additional information has been obtained that can be useful for early diagnosis and proper treatment. We also highlight the current pitfalls and limitations of cancer checkpoint immunotherapy and how novel research in the fields of personalized cancer vaccines, autoimmunity, the microbiome, the tumour microenvironment, and metabolomics is aiming to solve those challenges. This review also gives an overview of the many discoveries and the progression of the use of some thalidomide analogues especially naphthalimides as anticancer agents and their applications to date; focusing mainly on mono-, bis-naphthalimide based structures, and their various derivatives (e.g. amines, amino acids, heterocyclic systems).

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