ESTROGEN ATTENUATES DIMETHYLHYDRAZINE-INDUCED COLON INJURY IN FEMALE RATS VIA ABROGATION OF OXIDATIVE STRESS AND INFLAMMATIONS

Document Type : Original Article

Authors

1 Department of Pharmacology and Toxicology, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo.

2 BSc ,Faculty of Pharmacy, Cairo University, Cairo, Egypt

3 Department of Pathology, Faculty of Medicine (Girls), Al-Azhar University, Cairo, Egypt.

Abstract

The involvement of estrogen, the female sex hormone, in a variety of gastrointestinal conditions has been documented. We studied the effect of endogenous and exogenous estrogen (estradiol benzoate, 30μg/kg/day S.C) for 8 weeks on early preneoplastic markers induced by the intraperitoneal injection of 1,2-dimethylhydrazine (20 mg/kg) in female rats. Either in sham rats or estradiol benzoate administered animals, estrogen abrogated tumor markers (CA 19.9 and CEA), decreased damage and inflammatory cells infiltration in colon tissue, attenuated oxidative stress markers (MDA, SOD, CAT, and GSH) and inflammatory mediators (IL-6 and IL-10).  In conclusion, the estrogen protects against colon injury by reducing precancerous colonic lesions and oxidative stress. The research sheds new light on the therapeutic benefits of estrogen against colon injury in rats.

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Al-Azhar Journal of Pharmaceutical Sciences
Volume 66, Issue 2 - Serial Number 2
September and October 2022
Pages 267-284

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