STUDY OF THE EFFECT OF DIBENZAZEPINE IN RENAL INJURY INDUCED BY CISPLATIN IN RATS

Indeed, cisplatin is a standard anti-cancer agent that is used in the management of different types of solid tumors. Unfortunately, cisplatin significantly accumulates in renal proximal tubular cells where nephrotoxicity is the main side effect limiting its clinical use. The present study was conducted to explore the possible nephroprotective effect of dibenzazepine against cisplatin-induced renal injury in rats. Rats received pre-treatment with three different doses of dibenzazepine for one week before giving cisplatin at a one single dose (7 mg/kg) intraperitoneally. The renal injury was determined by measuring nephrotoxicity markers as well as histopathological investigation.  Dibenzazepine attenuated the elevation in blood urea nitrogen and serum creatinine levels. Moreover, the nephroprotective effect of dibenzazepine was further confirmed histopathologically. In conclusion, these findings show that dibenzazepine provides protection against renal injury induced by cisplatin.