THERAPEUTIC EFFECTS OF PINOCEMBRIN ON INDOMETHACIN-INDUCED GASTRIC ULCER MODEL IN RATS

Indomethacin considered one of the most commonly used NSAIDs to treat pain and inflammation among elder patients. Ironically, it has high risk of gastrointestinal complication, ulceration and in some cases perforation. Pinocembrin is one of the natural flavonoid present in honey and posses anti-inflammatory, anti-oxidant, and anti-apoptotic activities. The present study was conducted to investigate the possible therapeutic effects of  Pinocembrin on indomethacin induced gastric ulcer model in rats. Animals either pre-treated with pinocembrin 50mg/kg for 3 days before ulcer induction with one single dose of indomethacin (48 mg/kg) orally or post-treated with pinocembrin 50mg/kg/3 days and 50mg/kg/5days after 1 hr of ulcer induction with same dose of indomethacin. The therapeutic effects were determined via measuring oxidative stress  markers as well as histopathological investigation.  Pinocembrin protected gastric tissues which was confirmed histopathologically. It also increased levels of CAT, GSH and decreased levels of MDA enzymes. In conclusion, these findings show that pinocembrin have therapeutic effects in indomethacin induced gastric ulcer.