Background: Nonalcoholic fatty liver disease (NAFLD) is emerging one of the major causes of chronic liver damage that includes a wide spectrum of liver injury ranging from steatosis to steatohepatitis evolving to fibrosis. Aim: This study was designed to evaluate the possible effect of EUG on NAFLD induced by high fat cholesterol diet. Methods:Rats were fed either normal rat chow diet (control) or high fat cholesterol diet and both received olive oil (10 mg/kg) for eight weeks to induce NAFLD model. Eugenol (10 mg/kg) was administrated to rats by oral intubation 3 times weekly for 8 weeks. Results:Our results showed that EUG significantly ameliorated the histopathological lesions induced by HFCD. Furthermore, HFCD induced a significant elevation in liver enzymes (alanine aminotransferase (ALT) and aspartate aminotransferase (AST)). This was significantly attenuated by EUG co-treatment. Conclusion:These findings indicate that EUG possess es a marked role in modulation of NAFLD.
Azab, M. (2017). EUGENOL AMELIORATES PATHOGENIC FEATURES IN EXPERIMENTAL MODEL OF NAFLD IN RATS. Al-Azhar Journal of Pharmaceutical Sciences, 56(2), 115-122. doi: 10.21608/ajps.2017.28465
MLA
Maryam Azab. "EUGENOL AMELIORATES PATHOGENIC FEATURES IN EXPERIMENTAL MODEL OF NAFLD IN RATS". Al-Azhar Journal of Pharmaceutical Sciences, 56, 2, 2017, 115-122. doi: 10.21608/ajps.2017.28465
HARVARD
Azab, M. (2017). 'EUGENOL AMELIORATES PATHOGENIC FEATURES IN EXPERIMENTAL MODEL OF NAFLD IN RATS', Al-Azhar Journal of Pharmaceutical Sciences, 56(2), pp. 115-122. doi: 10.21608/ajps.2017.28465
VANCOUVER
Azab, M. EUGENOL AMELIORATES PATHOGENIC FEATURES IN EXPERIMENTAL MODEL OF NAFLD IN RATS. Al-Azhar Journal of Pharmaceutical Sciences, 2017; 56(2): 115-122. doi: 10.21608/ajps.2017.28465