Document Type : Original Article
Medicinal Pharmaceutical Chemistry & Drug Design Department, Faculty Of Pharmacy. Al-Azhar University
Department of Pharmaceutical Medicinal Chemistry & Drug Design, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt
Cancer is a global health challenge; it impacts the quality of life and its treatment is associated with several side effects. Resistance of the cancer cells to the existing drugs has led to search for novel anticancer agents. Pyrimidine, a privileged scaffold, is part of living organisms and plays vital role in various biological procedures as well as in cancer pathogenesis. Due to resemblance in structure with the nucleotide base pair of DNA and RNA, it is recognized as valuable compound in the treatment of cancer.
Many novel pyrimidine derivatives have been designed and developed for their anticancer activity in the last few years. The present review aims to focus on the structure of pyrimidine derivatives as anticancer agent from the last decade.
In summary, the development of more potent and efficacious anticancer drugs with pyrimidine scaffold will continue to be a promising scaffold over the next 20 years.