Human phosphatidyl inositol mannoside kinases (Pim kinases) are important biological target for discovery of new anticancer agents. In addition, Pyrimidines have a good contribution as building blocks of many anticancer agents. Hence, a literature survey about Pim kinases inhibitors and pyrimidine-based anticancer agents have been achieved. In this survey, we introduced Pim kinase inhibitors under clinical assessment including imidazo[1,2-b]pyridazines, isatins, thiazolidine-2,4-diones, pyridinamines, and diaminopyrazoles. In addition, Pim kinase inhibitors under development were presented. These compounds include pyridine-quinolines, benzimidazoles indoles, cyano pyridines, pyridothieno[3,2-d]pyrimidin-4-ones, oxadiazole, and 3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-ones. Furthermore, different pyrimidine-based anticancer agents have been discussed.
issa, I., Hammam, A., Sakr, H., & Ayyad, R. (2023). PIM KINASES INHIBITORS AND PYRIMIDINE-BASED ANTICANCER AGENTS. Al-Azhar Journal of Pharmaceutical Sciences, 67(1), 68-83. doi: 10.21608/ajps.2023.311247
MLA
ibrahim issa; Ahmed Hammam; Helmy Sakr; Rezk Ayyad. "PIM KINASES INHIBITORS AND PYRIMIDINE-BASED ANTICANCER AGENTS". Al-Azhar Journal of Pharmaceutical Sciences, 67, 1, 2023, 68-83. doi: 10.21608/ajps.2023.311247
HARVARD
issa, I., Hammam, A., Sakr, H., Ayyad, R. (2023). 'PIM KINASES INHIBITORS AND PYRIMIDINE-BASED ANTICANCER AGENTS', Al-Azhar Journal of Pharmaceutical Sciences, 67(1), pp. 68-83. doi: 10.21608/ajps.2023.311247
VANCOUVER
issa, I., Hammam, A., Sakr, H., Ayyad, R. PIM KINASES INHIBITORS AND PYRIMIDINE-BASED ANTICANCER AGENTS. Al-Azhar Journal of Pharmaceutical Sciences, 2023; 67(1): 68-83. doi: 10.21608/ajps.2023.311247
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