COMPARATIVE STUDY AMONG THREE MANIPULATING RATIO SPECTRA METHODS FOR THE DETERMINATION OF MOLNUPIRAVIR IN PRESENCE OF ITS ACID-INDUCED DEGRADATION PRODUCT

Document Type : Original Article

Authors

1 Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy (Boys), Al-Azhar University,11751, Nasr City, Cairo, Egypt

2 1Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy (Boys), Al-Azhar University,11751, Nasr City, Cairo, Egypt

3 Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy (Boys), Al-Azhar University,11751, Nasr City, Cairo, Egypt.

4 Armed Forces Collage Of Medicine Hospital (AFCMH),Military Medical Academy (MMA) Cairo, Egypt

Abstract

The main purpose of this work is to establish three simple, sensitive, accurate and precise spectrophotometric methods manipulating ratio spectra for determination of molnupiravir in bulk powder and in pharmaceutical preparation in the presence of its acid-induced degradation product. Ratio derivative, ratio difference and mean centering of ratio spectra are simple, rapid and selective methods using manipulation of ratio spectra for the determination of components having overlapping spectra. The suggested methods were validated in compliance with the ICH guidelines and were successfully applied for determination of molnupiravir in bulk powder and in pharmaceutical preparation in the presence of its acid-induced degradation product.


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