INSIGHTS INTO MOLECULAR GLUE DEGRADERS: A REVIEW

Document Type : Original Article

Authors

1 Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo 11884, Egypt.

2 Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo 11884, Egypt

Abstract

Researchers in drug discovery are continually investigating new approaches to develop potential anticancer agents that are effective, safe, tolerable, and exhibit reduced resistance. Targeted protein degraders (TPD) represent a progressive paradigm in drug discovery. Conventional small molecules are generally designed to inhibit specific targets, whereas molecular glues function to recruit critical problematic proteins to the ubiquitin-proteasome system (UPS), resulting in the degradation of disease-causing proteins through proteolysis. This study highlights the critical functions of TPD, particularly molecular glue degraders, in combating cancer and their implications for anticancer strategies. We aim to summarize recent advancements and offer insights into the development of medications associated with TPD technologies.

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