HIBISCUS SABDARIFFA AQUEOUS EXTRACT AMELIORATES THIOACETAMIDE-INDUCED HEPATIC ENCEPHALOPATHY IN GUINEA PIGS: ROLE OF AMMONIA EXTRACTION

Alalkam, Essam

doi:10.21608/ajps.2018.46638

HIBISCUS SABDARIFFA AQUEOUS EXTRACT AMELIORATES THIOACETAMIDE-INDUCED HEPATIC ENCEPHALOPATHY IN GUINEA PIGS: ROLE OF AMMONIA EXTRACTION

Document Type : Original Article

Author

Essam Alalkam

Medical Pharmacology Dpt, Faculty of Medicine, Cairo University, Egypt

10.21608/ajps.2018.46638

Abstract

The current work assessed the preventive and therapeutic potential of Hibiscus sabdariffa “HS” aqueous extract (HSE) on thioacetamide (TAA)-induced hepatic encephalopathy (HE) associated with the acute liver injury. Method: guinea pigs were divided into: Group 1 (Control group n=24) which wasfurther subdivided into 4 subgroups; Group “1-a” (non-treated); Group “1-b” given HSE for 3 days and sacrificed on the 4^th day; Group “1-c” given TAA for 3 days and sacrificed on the 4^th day; Group “1-d” given the TAA doses for 3 days and sacrificed on the 7^th day; Group 2 (Preventive) given TAA and HSE doses concurrently for 3 days and sacrificed on the 4^th day. Group 3 (Therapeutic) given 3-days TAA followed by 3-days HSE doses and sacrificed on the 7^th day. Results: Preventive and therapeutic HSE resulted in significant amelioration of the TAA-induced hepatic encephalopathy with faster recovery of animals on the 7^th day associated with significant improvement in the biochemical parameters of liver injury including the ammonia extraction ratio indicating functional hepatic improvement. In addition, there was a significant improvement in brain edema. Conclusion: HSE has both preventive and therapeutic effects on TAA-induced hepatic encephalopathy and liver injury in guinea pigs