PHYTOCHEMICAL AND BIOLOGICAL INVESTIGATION OF IXORA FINLAYSONIANA WALL. EX. G. DON. GROWING IN EGYPT.

Shawky, Mohamed

doi:10.21608/ajps.2018.6635

PHYTOCHEMICAL AND BIOLOGICAL INVESTIGATION OF IXORA FINLAYSONIANA WALL. EX. G. DON. GROWING IN EGYPT.

Document Type : Original Article

Author

Mohamed Shawky

FACULTY OF PHARMACY, EL-NAHDA UNIVERCITY, PHARMACOGNOSY DEPT. BENI-SWAIF, EGYPT AND POLICE HOSPITAL, NASR-CITY CAIRO, EGYPT.

10.21608/ajps.2018.6635

Abstract

Five flavonoid compounds; 5, 5`-dihydroxy-3, 6, 7, 3`, 4`-penta-methoxy-flavone( Azazieh H et al., 2010 ); 5-hydroxy-3, 6, 7, 3`, 4`, 5`-hexa-methoxy-flavone (Balandrin et al., 1993); 5, 7,4` tri-hydroxy-flavone[Apigenin]( Mukherjee et al., 2003); 5, 7, 4`-tri-hydroxy-6-methoxy-flavone[6-methoxy-apigenin] (Verma & Singh, 2008);Apigenin-4`-O-β-D-glucopyranoside (Metcalfe & Chalk, 1970).In addition to threepentacyclic triterpinoids; 3-Lup-20(29)-en-3-ol[Lupeol] (Baily, 1960),3-Lup-20(29)-en-3,28-diol [Betulin] (Kirtikar & Basu, 1975), and ursolic acid-3-O--D- glucopyranoside (Hortus, 1976) were isolated from the ethyl acetatesoluble fraction of the 70 % ethanolic extract of Ixora finlaysoniana. The structures of these compounds were determined by extensive use of UV, ESI-MS, and NMR spectroscopy. The Ethyl acetate fraction and its individual components showed significant antiradical activity by bleaching 1,1-diphenyl-2-picrylhydrazyl radical SC% ranging from (81.63 to 52.68 %) which was comparable to ascorbic acid (SC%72.55) and BHT (SC% 58.82).