THE EFFECTS OF CARVEDILOL AND Q10 ON ISOPRENALINE-INDUCED CARDIOTOXICITY: ELECTROCARDIOGRAPHIC, BIOCHEMICAL AND HISTOPATHOLOGICAL EVALUATION IN RATS.

Objective: To assess the therapeutic effect of combining of Carvedilol and Q10 on electrocardiographic, biochemical and histopathological changes in isoprenaline induced myocardial infarction. Methods: Myocardial infarction was induced in rats by subcutaneous (s.c) injection of isoprenaline (85mg/kg) for two consecutive days at an interval of 24 h. Rats were treated orally (p.o) with Carvedilol at dose (5 mg/kg/day) and Q10 at dose (10 mg/kg/day) for a period of 14 days. At the end of experiment electrocardiographic, biochemical and histopathological changes were monitored from control and experimental groups. Results: ISP intoxicated rats showed a significant tachycardia , elevation ST and prolongation of QTc (i.e. ST, QTc & HR) due to conduction abnormalities, increased serum creatine kinase isoenzyme-MB (CK-MB) Treatment with Carv+Q10 significantly improved the ISP induced alteration in ECG, biochemical and histopathological changes. Conclusions: The present result shows that treatment with Carv+Q10 significantly attenuates myocardial infarction in ISP-intoxicated rats.