• Home
  • Browse
    • Current Issue
    • By Issue
    • By Author
    • By Subject
    • Author Index
    • Keyword Index
  • Journal Info
    • About Journal
    • Aims and Scope
    • Editorial Board
    • Publication Ethics
    • Peer Review Process
  • Guide for Authors
  • Submit Manuscript
  • Reviewers
  • Contact Us
 
  • Login
  • Register
Home Articles List Article Information
  • Save Records
  • |
  • Printable Version
  • |
  • Recommend
  • |
  • How to cite Export to
    RIS EndNote BibTeX APA MLA Harvard Vancouver
  • |
  • Share Share
    CiteULike Mendeley Facebook Google LinkedIn Twitter
Al-Azhar Journal of Pharmaceutical Sciences
arrow Articles in Press
arrow Current Issue
Journal Archive
Volume Volume 63 (2021)
Volume Volume 62 (2020)
Volume Volume 61 (2020)
Volume Volume 60 (2019)
Volume Volume 59 (2019)
Volume Volume 58 (2018)
Volume Volume 57 (2018)
Volume Volume 56 (2017)
Volume Volume 55 (2017)
Volume Volume 54 (2016)
Volume Volume 53 (2016)
Volume Volume 52 (2015)
Volume Volume 51 (2015)
Volume Volume 50 (2014)
Issue Issue 2
Volume Volume 49 (2014)
Volume Volume 48 (2013)
Volume Volume 47 (2013)
Volume Volume 46 (2012)
Volume Volume 45 (2012)
Abu-Seada, H. (2014). STABILITY – INDICATING SPECTROPHOTOMETRIC METHODS FOR DETERMINATION OF LAMOTRIGINE IN PURE FORM AND PHARMACEUTICAL PREPARATIONS. Al-Azhar Journal of Pharmaceutical Sciences, 50(2), 67-83. doi: 10.21608/ajps.2016.6934
Hamed Abu-Seada. "STABILITY – INDICATING SPECTROPHOTOMETRIC METHODS FOR DETERMINATION OF LAMOTRIGINE IN PURE FORM AND PHARMACEUTICAL PREPARATIONS". Al-Azhar Journal of Pharmaceutical Sciences, 50, 2, 2014, 67-83. doi: 10.21608/ajps.2016.6934
Abu-Seada, H. (2014). 'STABILITY – INDICATING SPECTROPHOTOMETRIC METHODS FOR DETERMINATION OF LAMOTRIGINE IN PURE FORM AND PHARMACEUTICAL PREPARATIONS', Al-Azhar Journal of Pharmaceutical Sciences, 50(2), pp. 67-83. doi: 10.21608/ajps.2016.6934
Abu-Seada, H. STABILITY – INDICATING SPECTROPHOTOMETRIC METHODS FOR DETERMINATION OF LAMOTRIGINE IN PURE FORM AND PHARMACEUTICAL PREPARATIONS. Al-Azhar Journal of Pharmaceutical Sciences, 2014; 50(2): 67-83. doi: 10.21608/ajps.2016.6934

STABILITY – INDICATING SPECTROPHOTOMETRIC METHODS FOR DETERMINATION OF LAMOTRIGINE IN PURE FORM AND PHARMACEUTICAL PREPARATIONS

Article 6, Volume 50, Issue 2 - Serial Number 50, September 2014, Page 67-83  XML PDF (1017.39 K)
Document Type: Original Article
DOI: 10.21608/ajps.2016.6934
Author
Hamed Abu-Seada
Analytical Chemistry Department, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt.
Abstract
Three simple, sensitive, accurate, and precise methods were developed for determination of lamotrigine (LTG) in bulk powder and pharmaceutical preparations. The first method depends on charge transfer complexing of LTG with chloranilic acid (CA) as will as with 2,3-Dichloro-5,6-Dicyano-1,4-benzoquinone (DDQ) to produce purple color measured at 520 and 588 nm for CA and DDQ respectively. Beer’s low was obeyed in the range of 25 –200 and 6- 42 µg ml-1 with LOD of 3.06 and 0.498 µg ml-1 and LOQ of 10.19 and 1.66 µg ml-1 respectively. The second method depends on ion pairing of LTG with bromothymol blue (BTB), bromophenol blue (BPB) and bromocresol green (BCG) to  produce red colored complexes measured at 419, 417 and 417 nm for the three reagents respectively. Beer’s low was obeyed in the range of 2 – 12 µg ml-1 for all reagents. LOD was found to be 0.56, 0.18 and 0.13 µg ml-1 while LOQ was 1.66, 1.86 and 0.53 respectively. The third method is the adopting of the first derivative spectrophotometry at 291 nm for direct determination of lamotrigine in presence of its degradation product. A linear relationship between peak height and drug concentration was obtained in the range of 10 – 70 µg ml-1.LOD and LOQ were found to be 0.68 and 2.26 µg ml-1 respectively. The percent recoveries ± RSD% of these methods were 99.52-100.36 ± 0.78-1.34, 99.65-100.48 + 0.85-1.38, and 99.62-100.26 ± 1.17-1.22 % respectively. The obtained results were compared with those of the reported method and no significant difference was observed regarding accuracy and precision
Keywords
lamotrigine; Charge-transfer and Ion-pair determinations - Stability - indicating first derivative spectrophotometry
Statistics
Article View: 52
PDF Download: 158
Home | Glossary | News | Aims and Scope | Sitemap
Top Top

Journal Management System. Designed by NotionWave.