SEMICARBAZONES AS ANTICONVULSANTS

Document Type : Original Article

Author

Medicinal and Pharmaceutical Chemistry Department, Pharmaceutical and Drug Industries Research Division, National Research Centre, Dokki, Giza,12622, Egypt

Abstract

Approximately 25% of epileptics’ convulsions are inefficiently controlled by currently available remedies; therefore the preparation of new antiepileptic drugs is of great interest. Aryl semicarbazones can be considered a new class of compounds presenting anticonvulsant activity. In addition, they can be orally administered. Semicarbazones derived from aromatic and unsaturated carbonyl compounds as well as from other precursors are reviewed together with their anticonvulsant profile.

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