In order to produce potent new leads for antidiabetic drugs, a new series of isoindoline-1,3-dione analogues bearing aryl sulfonylurea moieties were synthesized and screened for their antihyperglycemic activity. Some of newly synthesized compounds were identified as active antihyperglycemic agents. Compounds N-(cyclohexylcarbamoyl)-4-[2-(1,3-dioxoisoindolin-2-yl) ethyl]benzenesulfon-amide(VIIo),N-(cyclopentylcabamoyl)-4-[2-(1,3-dioxoiso- indolin-2-yl)ethyl] benzene sulfonamide (VIIp), N-(butylcabamoyl)-4-[2-(1,3-dioxoisoindolin-2-yl)ethyl]benzenesulfonamide(VIIq),N-(cyclohexylcarbamoyl) -4- [ ( 1, 3- dioxo - isoindolin- 2 – yl ) methyl ] benzenesulfonamide (VIIh) and N-(propylcabamoyl)-4-[2-(1,3-dioxoisoindolin-2-yl)ethyl]benzenesulfonamide (VIIr) proved to be the most active members of this study, as compered to to the reference gliclazide. They showed serum glucose reduction values of 52%, 48% 45%, 44% and 44%, respectively. The detailed synthesis and biological screening data are reported.
Eissa, I. (2013). SYNTHESIS OF SOME NEW DERIVATIVES OF ISOINDOLINE-1,3-DIONE NUCLEUS FOR ANTIHYPERGLYCEMIC EVALUATION. Al-Azhar Journal of Pharmaceutical Sciences, 48(2), 120-129. doi: 10.21608/ajps.2013.7100
MLA
Ibrahim Eissa. "SYNTHESIS OF SOME NEW DERIVATIVES OF ISOINDOLINE-1,3-DIONE NUCLEUS FOR ANTIHYPERGLYCEMIC EVALUATION", Al-Azhar Journal of Pharmaceutical Sciences, 48, 2, 2013, 120-129. doi: 10.21608/ajps.2013.7100
HARVARD
Eissa, I. (2013). 'SYNTHESIS OF SOME NEW DERIVATIVES OF ISOINDOLINE-1,3-DIONE NUCLEUS FOR ANTIHYPERGLYCEMIC EVALUATION', Al-Azhar Journal of Pharmaceutical Sciences, 48(2), pp. 120-129. doi: 10.21608/ajps.2013.7100
VANCOUVER
Eissa, I. SYNTHESIS OF SOME NEW DERIVATIVES OF ISOINDOLINE-1,3-DIONE NUCLEUS FOR ANTIHYPERGLYCEMIC EVALUATION. Al-Azhar Journal of Pharmaceutical Sciences, 2013; 48(2): 120-129. doi: 10.21608/ajps.2013.7100
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