EFFECT OF MORINGAOLEIFERA LEAVES EXTRACT AGAINST ACETAMINOPHEN INDUCED HEPATOTOXICITY IN ALBINO RATS.

Abstract
            This study was carried out to evaluate the the effect of moringaoleiferaleavesExtract against liver injury induced by APAP in rats.The experimental animals were divided into six groups of male albino rats. Aqueous extract of Moringaoleifera (AMO) and hydroalcoholic extract of Moringaoleifera (HAMO) were prepared and pre-administered orally to rats at dose 500 mg/kg body weight; p.ofor a period of 28 days prior to a singleoraldose of APAP 3 g/kg body weight; p.o.The results showed that APAP induced a significant rise in the activities of aspartate amino transferase(AST), alanine amino transferase (ALT), alkaline phosphatase (ALP)and the level of malondialdehyde (MDA)besides reduction in the activities of glutathione reductase (GR), superoxide dismutase (SOD) and catalase (CAT).The activities of AST, ALT, ALP and the level of MDAwere significantly decreasedwhilethe activities of GR, SOD and CATwere significantlyincreased in rats pre-administered with HAMO and AMO priorto APAP treatmentcompared to the group treated with APAP alone. Rats pre-administered with HAMO priorto APAP treatmenthave provided more significant protectioninthe activities of liver enzymes and antioxidants enzymes than rats pre-administered with AMO priorto APAP treatment.Pre-administered of HAMO and AMO significantly prevented the hepatocellularchanges associated with APAPtreatment.The results from the present study suggestedthat the two extracts of moringaoleiferaleaves (HAMO and AMO) possess a remarkablehepatoprotective and antioxidantactivity against APAP induced hepatotoxicity.