5-(p-Tolyl)-2-[(p-tolylethylidene)hydrazino] thiazole (3) and 3-[(p-tolylethylidene )amino]-2-thiohydantoin (6) have been prepared via cyclization of p-methyl acetophenone thiosemicarbazone (2) with p-methylphenacyl bromide and ethyl chloroacetate in presence of fused sodium acetate . Acetylation of 2,3 and 6 with acetic anhydride afforded the corresponding diacetyl derivative(5) and mono acetyl derivatives (4 and 7). Reaction of 2-thiohydantoin (6) with thiophene-2-carboxaldhyde and chloroacetic acid gives 5-(thiophen-2-ylidene)-3-[(p-tolylethylidene)amino] -2-thiohydantoin (8) and 3-[(p- tolylethylidene )amino] -2-thiohydantoin-5-yl acetic acid (10) . The mass spectral fragmentation patterns of some prepared thiazole and 2-thiohydantoin derivatives have been investigated in order to elucidate the structure of the synthesized compounds. The prepared compounds also exhibited antimicrobial activity.
Abd El Hady, H. (2012). SYNTHESES, ANTIMICROBIAL ACTIVITY AND MASS SPECTRAl INVESTIGATION OF SOME NEW THIOHYDANTOIN AND THIAZOLE DERIVATIVES.. Al-Azhar Journal of Pharmaceutical Sciences, 45(1), 42-55. doi: 10.21608/ajps.2012.7150
MLA
haba Abd El Hady. "SYNTHESES, ANTIMICROBIAL ACTIVITY AND MASS SPECTRAl INVESTIGATION OF SOME NEW THIOHYDANTOIN AND THIAZOLE DERIVATIVES.", Al-Azhar Journal of Pharmaceutical Sciences, 45, 1, 2012, 42-55. doi: 10.21608/ajps.2012.7150
HARVARD
Abd El Hady, H. (2012). 'SYNTHESES, ANTIMICROBIAL ACTIVITY AND MASS SPECTRAl INVESTIGATION OF SOME NEW THIOHYDANTOIN AND THIAZOLE DERIVATIVES.', Al-Azhar Journal of Pharmaceutical Sciences, 45(1), pp. 42-55. doi: 10.21608/ajps.2012.7150
VANCOUVER
Abd El Hady, H. SYNTHESES, ANTIMICROBIAL ACTIVITY AND MASS SPECTRAl INVESTIGATION OF SOME NEW THIOHYDANTOIN AND THIAZOLE DERIVATIVES.. Al-Azhar Journal of Pharmaceutical Sciences, 2012; 45(1): 42-55. doi: 10.21608/ajps.2012.7150
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