The oxo-chromene-6-carbaldehyde derivative 1 was used as a starting material for the synthesis of some novel pyrano[3,2-b] xanthene-4,7-dione 2 and chromen-oxazol-5-(4H)-one derivatives 4,5. Furthermore, the oxazolone derivative 4 was used as key intermediates to synthesize some novel imidazol derivatives 6-14. The structures of target compounds were confirmed by elemental analyses and spectral data. All the target compounds were subjected to in-vitro antitumor activity against breast and colon human tumor cell lines (MCF7 and HCT). Most of the screened compounds showed interesting cytotoxic activities compared to a reference drug.
Saleh, N. (2012). SYNTHESIS AND ANTICANCER ACTIVITY OF IMIDAZOLE DERIVATIVES INCORPORATING CHROMENE MOIETY. Al-Azhar Journal of Pharmaceutical Sciences, 45(1), 312-322. doi: 10.21608/ajps.2012.7244
MLA
Nashwa Saleh. "SYNTHESIS AND ANTICANCER ACTIVITY OF IMIDAZOLE DERIVATIVES INCORPORATING CHROMENE MOIETY". Al-Azhar Journal of Pharmaceutical Sciences, 45, 1, 2012, 312-322. doi: 10.21608/ajps.2012.7244
HARVARD
Saleh, N. (2012). 'SYNTHESIS AND ANTICANCER ACTIVITY OF IMIDAZOLE DERIVATIVES INCORPORATING CHROMENE MOIETY', Al-Azhar Journal of Pharmaceutical Sciences, 45(1), pp. 312-322. doi: 10.21608/ajps.2012.7244
VANCOUVER
Saleh, N. SYNTHESIS AND ANTICANCER ACTIVITY OF IMIDAZOLE DERIVATIVES INCORPORATING CHROMENE MOIETY. Al-Azhar Journal of Pharmaceutical Sciences, 2012; 45(1): 312-322. doi: 10.21608/ajps.2012.7244