SYNTHESIS AND CHARACTERIZATION OF POLY(VINYL ALCOHOL)-HYALURONIC ACID BLENDED HYDROGEL MEMBRANES

Document Type : Original Article

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Polymer Materials Research Department, Advanced Technology & New Materials Research Institute (ATNMRI), City of Scientific

Abstract

Poly(vinyl alcohol)PVA is a hydrophilic polymer and water soluble . It is used in many biomedical and pharmaceutical applications, due to its advantages such as: non-toxic, non-carcinogenic, and biodegradable characteristics with the ease of processing. Physically cross-linked hydrogel membranes composed of different amounts of hyaluronic acid (HA) blend with (PVA) were prepared by freeze–thawing method. This freezing–thawing cycle was repeated for three consecutive cycles. Properties of (PVA–HA) hydrogel membrane such as gel fraction, swelling, mechanical properties(tensile strength, elongation to break),degradation and protein adsorption were investigated. With the increasing of HA content, the gel fraction, the maximum tensile strength and elongation at break(%) of (PVA-HA) hydrogel membranes were decreased. Furthermore, with the increase of HA content, the swelling, the protein adsorption and the hydrolytic degradation of PVA-HA hydrogel membrane were increased.After soaking of hydrogel membrane for three days in phosphate buffer saline (PBS),  the maximum weight loss of PVA–HA hydrogel membranes ranged between 18% and 70% according to HA content, this  indicates that  they are biodegradable.

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